How Long Does Oxycodone Stay in Your System: Blood and More

overview Oxycodone is an opioid drug used to relieve moderate to severe pain in adults who can ’ thymine be treated with other pain medications. Oxycodone may be prescribed following an injury, injury, or major operating room. It may besides be prescribed to treat other types of austere pain, like cancer pain. Brand names for immediate-release oxycodone include :

  • Oxaydo
  • Roxycodone
  • Roxybond
  • Oxy IR

Brand names for controlled or extended-release versions of oxycodone include :

  • OxyContin CR (controlled-release)
  • Xtampza ER (extended-release)

There are besides combination medications that include oxycodone, such as :

  • oxycodone combined with acetaminophen (Percocet)
  • oxycodone combined with acetaminophen (Xartemis XR)
  • oxycodone combined with aspirin (generic available)
  • oxycodone combined with ibuprofen (generic available)

Oxycodone is derived from the poppy plant. It binds to the mu opioid receptor and blocks the spirit of trouble. Since oxycodone works in the pleasure centers of the brain, it has a high electric potential for misuse and addiction. For this reason, oxycodone is classified as a federal controlled means ( C-II ). If you ’ ve been prescribed oxycodone, you may be curious as to how farseeing the effects will last in your body, and how long the medication may show up on a drug test. It ’ south besides significant to understand what to do if you decide to stop taking oxycodone. abruptly stopping the medication can lead to withdrawal symptoms.

How long does it take to feel the effects of oxycodone?

The total of oxycodone needed for analgesia ( pain relief ) varies widely between people. normally, a sophisticate will start you on a broken venereal disease and then increase the drug lento until your trouble is well controlled. People who have taken an opioid medicine before may need to take a higher acid in orderliness to experience pain relief. Oxycodone is taken by mouth ( oral ) and should be taken with food. You should start feeling the effects of oxycodone in just 20 to 30 minutes. Oxycodone reaches acme concentrations in the bloodstream in roughly one to two hours following consumption. Extended- and controlled-release formulations can take three to four hours to reach extremum concentration in the bloodstream. Over time, you may build up a tolerance to oxycodone. This means it may take longer to feel the pain relief or the relief may not feel as potent. When this happens, your sophisticate may want to increase your drug or switch you to a different character of pain medicine. Don ’ t take a larger acid of oxycodone without speaking to your doctor inaugural.

How long does it take for the effects of oxycodone to wear off?

One way to find out how hanker a drug will death in your body is to measure its half life. The half life is the clock it takes for one-half of the drug to be eliminated from the body. Immediate-release formulations of oxycodone have average half life of 3.2 hours. In other words, it takes 3.2 hours for the average person to eliminate half of the acid of oxycodone. Controlled/extended-release formulations of oxycodone have a longer half life of about 4.5 hours to 5.6 hours, on median. It takes respective half-lives to fully eliminate a drug. Since everyone metabolizes medications differently, the half life will vary from person to person. For most people, oxycodone will fully clear the blood within 24 hours, but it can still be detected in the saliva, urine, or hair for longer than that. Oxycodone can be detected in :

  • saliva for one to four days after the last dose is taken
  • urine for three to four days after the last dose is taken
  • hair for up to 90 days after the last dose is taken

You will likely stop “ feeling ” the pain relief of oxycodone long before it amply clears your body. This is why your sophisticate may have you take a unmarried pad of oxycodone every four to six hours while you ’ re in pain. Controlled or extended-release formulations last long, so they are normally taken every 12 hours.

Factors that influence how long the effects of oxycodone last

A number of factors can influence the time it takes for oxycodone to clear the body. These include :


The blood concentrations of oxycodone have been shown to be 15 percentage higher in the aged ( over long time 65 ) compared to younger adults. It may take longer for aged people to clear oxycodone from their system .


According to the package cut-in for OxyContin, oxycodone concentration for healthy female subjects was up to 25 percentage higher than in males. The like was seen in studies for Xtampza ER. The rationality for this is ill-defined .

Liver function

The average half life of oxycodone increases by 2.3 hours in people with liver dysfunction. This means it will take longer to clear oxycodone from the body .

Kidney function

One survey found that the average half life of oxycodone increases by one hour in people with kidney problems .

How long you’ve been taking oxycodone

If you take oxycodone regularly, it can accumulate in fatso tissues in your body. This means that the longer you ’ ve been taking oxycodone, the longer it will take to be completely eliminated from the body .


The effects of oxycodone are increased if you consume alcohol. not lone will it take longer to clear oxycodone from your consistency, but it can besides lead to dangerous side effects, including a potentially black overdose .

Other medications

Oxycodone is cleared by your body through a pathway known as cytochrome P450 3A ( CYP3A ). Drugs that suppress CYP3A4 make it more difficult for your body to break down oxycodone. Taking oxycodone with the trace medications could result in dangerous problems, including respiratory natural depression :

  • macrolide antibiotics, such as erythromycin
  • azole antifungal agents, such as ketoconazole
  • protease inhibitors

alternatively, drugs that induce CYP3A, such as rifampin, may decrease the effects of oxycodone .

Withdrawal symptoms

Don ’ metric ton catch taking oxycodone abruptly without consulting your repair because you can have serious withdrawal symptoms. Withdrawal symptoms occur when the soundbox has become dependant on a drug. If you experience withdrawal symptoms, it doesn ’ t necessarily mean you ’ re addicted to oxycodone. Dependence is different from addiction. In drug addiction, the torso has become used to the presence of a drug, so if you stop taking that drug abruptly, you will experience predictable symptoms known as a withdrawal symptoms. These may include :

  • restlessness
  • watery eyes
  • runny nose
  • yawning
  • inability to sleep
  • muscle cramps
  • joint aches
  • vomiting
  • sweating
  • fast breathing
  • fast heartbeat

Dependence normally doesn ’ thymine happen until after several weeks of taking the drug systematically. Your doctor may reduce your dose gradually over time to prevent withdrawal. This is called tapering. It ’ sulfur recommended that the dose is decreased gradually while monitoring carefully for signs and symptoms of withdrawal. If you do experience coitus interruptus symptoms, they can be classified as meek, mince, or severe. Everyone experiences secession differently, but in general symptoms begin to improve within 72 hours and decrease significantly within a week. Your doctor can help you manage your symptoms .


The annoyance relief effect of immediate-release oxycodone will wear off within four to six hours, but the drug may still be detected in the saliva and urine for up to four days hours and in the haircloth for 90 days after the last drug. There are besides a total of factors that could alter the time it takes for oxycodone to clear the body, including :

  • age
  • gender
  • liver and kidney health
  • how long you’ve been taking oxycodone
  • certain medications

You shouldn ’ triiodothyronine drink alcohol or take other street drugs while taking oxycodone as these will increase your risk of experiencing major side effects, including dangerous breathe problems. Tell your doctor of the church if you ’ re taking any other medications. never take more than your order acid of oxycodone, flush if you feel that the medicine is not working. It ’ s possible to overdose on oxycodone.

Seek emergency care if you experience any of the following symptoms after taking oxycodone :

  • difficulty breathing
  • slowed or stopped breathing
  • cold, clammy skin
  • loss of consciousness or coma
  • extreme sleepiness
  • constricted pupils
  • limp or weak muscles
  • vomiting

Opioids such as oxycodone have been associated with dangerous health issues, including addiction and overdose. In 2015, more than 20,000 people died from opioid prescription-related overdoses in the United States, according to the american Society of Addiction Medicine. You should cautiously read the data contained in the product label before you begin treatment with oxycodone. alone take your prescribed dose. Contact your doctor of the church if you have any questions or concerns .

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